Apolipoprotein E Mimetic Promotes Functional and Histological Recovery in Lysolecithin-Induced Spinal Cord Demyelination in Mice
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چکیده
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Apolipoprotein E Mimetic Promotes Functional and Histological Recovery in Lysolecithin-Induced Spinal Cord Demyelination in Mice
OBJECTIVE Considering demyelination is the pathological hallmark of multiple sclerosis (MS), reducing demyelination and/or promoting remyelination is a practical therapeutic strategy to improve functional recovery for MS. An apolipoprotein E (apoE)-mimetic peptide COG112 has previously demonstrated therapeutic efficacy on functional and histological recovery in a mouse experimental autoimmune e...
متن کاملElectrophysiological and Histological Study of Lysolecithin-Induced Local Demyelination in Adult Mice Optic Chiasm
Introduction: Demyelination is one of the main causes of neurological disability. It is the end product of numerous pathological processes, multiple sclerosis (MS) being the most common cause. More than 70% of the MS patients suffer from optic disturbances. This disease commonly affects the optic pathway, particularly the optic nerves and chiasm. Several attempts have been made to produce a ...
متن کاملelectrophysiological and histological study of lysolecithin-induced local demyelination in adult mice optic chiasm
introduction: demyelination is one of the main causes of neurological disability. it is the end product of numerous pathological processes, multiple sclerosis (ms) being the most common cause. more than 70% of the ms patients suffer from optic disturbances. this disease commonly affects the optic pathway, particularly the optic nerves and chiasm. several attempts have been made to produce a sui...
متن کاملNogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm
BACKGROUND Inhibitory factors have been implicated in the failure of remyelination in demyelinating diseases. Myelin associated inhibitors act through a common receptor called Nogo receptor (NgR) that plays critical inhibitory roles in CNS plasticity. Here we investigated the effects of abrogating NgR inhibition in a non-immune model of focal demyelination in adult mouse optic chiasm. METHODO...
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ژورنال
عنوان ژورنال: Journal of Neurology & Neurophysiology
سال: 2013
ISSN: 2155-9562
DOI: 10.4172/2155-9562.s12-010